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NIPRO JMI PharmaProduct Description
Empagliflozin and metformin hydrochloride is a fixed-dose combination therapy designed to improve glycemic control in adults with type 2 diabetes mellitus by utilizing two distinct, complementary mechanisms. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that lowers blood glucose by preventing the kidneys from reabsorbing glucose, thereby promoting its excretion through urine. Metformin hydrochloride, a biguanide, complements this by decreasing hepatic glucose production, reducing intestinal glucose absorption, and enhancing insulin sensitivity in peripheral tissues. Beyond blood sugar management, this combination is often favored for its secondary benefits, including potential weight loss, a low risk of hypoglycemia when used without insulin secretagogues, and significant cardiovascular and renal protection. Common side effects include gastrointestinal upset from metformin and an increased risk of urinary tract or genital mycotic infections due to the glucosuric effect of empagliflozin.
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