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Losartan Potassium
Linagliptin
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1 Strip = 14 Tablets
Nevian Lifescience PLCProduct Description
The combination of Sacubitril and Valsartan represents a first-in-class treatment known as an Angiotensin Receptor-Neprilysin Inhibitor (ARNI), specifically indicated for the management of chronic heart failure with reduced ejection fraction. This synergistic pairing works by simultaneously targeting two key pathways: Sacubitril is a prodrug that inhibits the enzyme neprilysin, thereby increasing the levels of beneficial natriuretic peptides that promote vasodilation and natriuresis, while Valsartan is an Angiotensin II Receptor Blocker (ARB) that counteracts the harmful effects of the renin-angiotensin-aldosterone system (RAAS) such as vasoconstriction and fluid retention. By enhancing the body’s natural protective mechanisms while inhibiting the overactive hormonal systems that drive heart failure progression, this combination significantly reduces cardiovascular mortality and the frequency of hospitalizations. Clinical administration requires careful monitoring of blood pressure, renal function, and potassium levels to ensure patient safety and therapeutic efficacy.
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