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1 Strip = 12 Tablets
Healthcare Pharmaceuticals LtdProduct Description
Orlistat is a potent, reversible gastric and pancreatic lipase inhibitor utilized for the long-term management of obesity and weight reduction. Unlike many other weight-loss medications, orlistat acts locally within the gastrointestinal tract and does not suppress appetite through the central nervous system. Its primary mechanism involves forming a covalent bond with the active serine site of lipases in the stomach and small intestine, preventing these enzymes from hydrolyzing dietary fats (triglycerides) into absorbable free fatty acids and monoglycerides. Consequently, approximately 30% of ingested fat passes through the digestive system unabsorbed, leading to a significant caloric deficit. Because of this mechanism, common side effects are gastrointestinal in nature, such as steatorrhea (oily spotting) and flatulence with discharge, which can be managed by adhering to a low-fat diet. Additionally, patients are typically advised to take a multivitamin supplement containing fat-soluble vitamins (A, D, E, and K) at bedtime, as orlistat can interfere with their absorption.
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