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Incepta Pharmaceuticals Ltd.Product Description
Dexlansoprazole is a third-generation proton pump inhibitor (PPI) and the R-enantiomer of lansoprazole, utilized primarily for the healing of erosive esophagitis and the treatment of symptomatic gastroesophageal reflux disease (GERD). It works by irreversibly binding to the H+ /K + -ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby suppressing the final step of gastric acid production. A defining characteristic of dexlansoprazole is its unique Dual Delayed Release (DDR) formulation, which utilizes two types of enteric-coated granules that release the drug at different pH levels and time intervals. This technology produces two distinct peaks in plasma concentration, extending the duration of acid suppression and providing 24-hour symptom relief with a single daily dose. Compared to older PPIs, its pharmacokinetics offer greater flexibility as it can be administered regardless of food intake, though clinical monitoring for long-term effects, such as potential magnesium deficiency or B12 malabsorption, remains important.
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