Product Description

Indications:Oramet is used to treat type 2 diabetes mellitus, especially in overweight patients when diet and exercise alone are insufficient. It can be used alone or with other antidiabetic drugs or insulin. It also helps reduce diabetes-related complications.Pharmacology:Metformin is a biguanide oral antidiabetic drug. It lowers blood glucose by reducing liver glucose production, decreasing intestinal absorption of glucose and improving insulin sensitivity. It does not usually cause hypoglycemia.Dosage and Administration:Adults: Start with 500 mg twice daily or 850 mg once daily with meals. Dose can be increased gradually up to 2000–2550 mg/day.Children (≥10 years): Start with 500 mg twice daily, up to 2000 mg/day.Extended-release: Start 500 mg once daily with evening meal, up to 2000 mg/day.Do not crush XR tablets.Drug Interactions:May interact with drugs like nifedipine, cationic drugs (e.g., digoxin), and medications that increase blood sugar (e.g., corticosteroids, diuretics). Monitoring is required.Contraindications:Contraindicated in severe renal impairment, metabolic acidosis, liver disease, severe infection, dehydration, alcoholism and conditions causing low oxygen supply.Side Effects:Common: nausea, vomiting, diarrhea, abdominal pain, loss of appetite.Rare: lactic acidosis, vitamin B12 deficiency, skin reactions.Pregnancy and Lactation:Insulin is preferred during pregnancy. Not recommended during breastfeeding due to limited safety data.Precautions and Warnings:Monitor kidney function regularly. Risk of lactic acidosis increases in renal impairment. May reduce vitamin B12 levels. Stop temporarily before surgery or contrast procedures.Use in Special Populations:Elderly patients require dose adjustment based on kidney function. Use cautiously in children and monitor growth.Overdose Effects:Overdose may cause lactic acidosis. Treatment includes supportive care and hemodialysis if needed.Therapeutic Class:Biguanide AntidiabeticStorage Conditions:Store below 30°C, protect from light and moisture, and keep out of reach of children.⚠️ Use under the supervision of a registered healthcare professional.